Scientists have found that a single change in a person’s genetic material can cause primary progressive MS. They say this finding could lead to a cure for a disease that cripples millions of people. Researchers have long suspected that multiple sclerosis resulted from some kind of interaction among genes. Individuals with that genetic interaction, they thought, were more likely than others to get sick. They also believed that something in the environment, such as a viral infection or lack of vitamins in the diet, could activate the disease. But Canadian researchers have found that is not the cause of the most severe form of multiple sclerosis. With primary progressive MS, a single mutated gene can greatly increase the risk for developing the disease. This single gene is called NR1H3. The Canadian researchers are with the University of British Columbia in Vancouver. They reported the findings in the journal Neuron. The researchers examined medical records for 2,000 Canadian families with family members who had MS.
Title: Scientists Discover Gene Responsible for Multiple Sclerosis
Content: <div id='article-page'><div id='article-content' data-media-url='//news-app-staging.s3.amazonaws.com' data-base-url='//news-app-staging.herokuapp.com' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/ms_audio.m4a' data-capture-url='//staging.analytics.lingraphica.com/events/capture_news' data-article-title='Scientists Discover Gene Responsible for Multiple Sclerosis' data-article-id='1612'><script src='//news-app-staging.herokuapp.com/javascripts/getscripts.js'></script><link rel='stylesheet' href='//news-app-staging.herokuapp.com/stylesheets/article.css' type='text/css' /><div class='article'><p><span data-start-time='0' data-end-time='9375'>Scientists have found that a single change in a person’s genetic material can cause primary progressive MS.</span> <span data-start-time='9375' data-end-time='17000'>They say this finding could lead to a cure for a disease that cripples millions of people.</span> <span data-start-time='17000' data-end-time='26792'>Researchers have long suspected that multiple sclerosis resulted from some kind of interaction among genes.</span> <span data-start-time='26792' data-end-time='34938'>Individuals with that genetic interaction, they thought, were more likely than others to get sick.</span> <span data-start-time='34938' data-end-time='46458'>They also believed that something in the environment, such as a viral infection or lack of vitamins in the diet, could activate the disease.</span> <span data-start-time='46458' data-end-time='55396'>But Canadian researchers have found that is not the cause of the most severe form of multiple sclerosis.</span> <span data-start-time='55396' data-end-time='65063'>With primary progressive MS, a single mutated gene can greatly increase the risk for developing the disease.</span> <span data-start-time='65063' data-end-time='70604'>This single gene is called NR1H3.</span> <span data-start-time='70604' data-end-time='77125'>The Canadian researchers are with the University of British Columbia in Vancouver.</span> <span data-start-time='77125' data-end-time='81313'>They reported the findings in the journal Neuron.</span> <span data-start-time='81313' data-end-time='89375'>The researchers examined medical records for 2,000 Canadian families with family members who had MS.</span> </p></div><div class='control-buttons-sticky' style='display:none;'><div class='control-buttons'><button title='Back' class='back' disabled='disabled'></button><button title='Play' class='play' disabled='disabled'></button><button title='Pause' class='pause' style='display:none;'></button><button title='Forward' class='forward' disabled='disabled'></button><button class='finished-reading' style='display:none;'>Done</button></div></div></div><div id='article-media'><div id='media-image'><img src='https://news-app-production.s3.amazonaws.com/articles/1121/ms_image.jpg'/></div></div><div id='question-content' style='display:none;'><div class='vocabulary_question question-container' data-question-id=6412 data-hint-location='9375' style='display:none;'><div class='question' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/what_does_cripple_mean.m4a'>What does cripple mean?</div><div class='choices' data-correct-choice='cause someone to become unable to move'><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/cranial_nerves.m4a'><span>cranial nerves</span></div><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/pieces_of_information.m4a'><span>pieces of information</span></div><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/a_scientist_who_studies_genetics.m4a'><span>a scientist who studies genetics</span></div><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/cause_someone_to_become_unable_to_move.m4a'><span>cause someone to become unable to move</span></div></div></div><div class='multiple_choice_question question-container' data-question-id=6413 data-hint-location='17000' style='display:none;'><div class='question' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/what_disease_are_the_scientists_researching.m4a'>What disease are the scientists researching?</div><div class='choices' data-correct-choice='multiple sclerosis'><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/epilepsy.m4a'><span>epilepsy</span></div><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/multiple_sclerosis.m4a'><span>multiple sclerosis</span></div><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/lupus.m4a'><span>lupus</span></div><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/diabetes.m4a'><span>diabetes</span></div></div></div><div class='sentence_completion_question question-container' data-question-id=6414 data-hint-location='55396' style='display:none;'><div class='question' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/a_single_mutated__blank__increases_the_risk_for_developing_ms.m4a'>A single mutated <span class='blank'>gene</span> increases the risk for developing MS.</div><div class='choices' data-correct-choice='gene'><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/cure.m4a'><span>cure</span></div><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/drug.m4a'><span>drug</span></div><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/gene.m4a'><span>gene</span></div><div class='choice' data-sound-name='https://news-app-production.s3.amazonaws.com/articles/1121/test.m4a'><span>test</span></div></div></div><div class='question-buttons'><button 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