Scientists say they are carrying out tests on monkeys, ferrets and other animals in the search for a vaccine for COVID-19. The testing can help researchers learn about how the vaccine affects the immune system, the body’s natural defense against disease. If a vaccine causes the immune system to react in the wrong way, it could worsen existing disease. Researchers have already been seeking tens of thousands of human subjects to take part in large COVID-19 vaccine studies. Efforts to find a vaccine to prevent COVID-19 have quickly increased as the disease continues spreading in a worldwide pandemic. Scientists have also turned to animals to help answer important questions about the development of a vaccine.