American drug maker Johnson & Johnson said Friday that its one-shot vaccine prevented COVID-19 in a large trial around the world. The vaccine, however, was less effective in South Africa where a worrisome variant is causing new infections. The Johnson & Johnson, or J&J, trial involved almost 44,000 volunteers. The company said the vaccine worked best in the United States with an efficacy rate of 72 percent. In Latin America, efficacy was 66 percent. J&J reported that South Africa saw the lowest efficacy rate of the vaccine, at 57 percent.